J Clin Dent 2009; 20 (Spec Iss): 17-22. Arginine, Calcium Carbonate, Aqua, Sorbitol, Aroma, Poloxamer 407, Sodium Monofluorophosphate, Cocamidopropyl betaine, Zinc oxide, Benzyl Alcohol, Cellulose Gum, Zinc Citrate, Sodium Bicarbonate, Tetrasodium Pyrophosphate, Xantham Gum, Sodium Saccharin, Sucralose, Limonene, CL77891, 1. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. Mason S, Hughes N, Sufi F, Bannon L, Maggio B, North M, et al. Dentin hypersensitivity. Favaro Zeola L, Soares PV, Cunha-Cruz J. Pak Oral Dent J. Therefore, this trial was planned to investigate the clinical efficacy of Pro-argin and strontium acetate for immediate pain relief in DH after one minute of topical application to fill the research gap associated with limited published evidence and risk of bias in selection, performance, attrition, and reporting as predicted by Pessoa et al. Patel VR, Shettar L, Thakur S, Gillam D, Kamala DN. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. ^Vs novamin/sodium fluoride technology and stannous fluoride/sodium fluoride technology (p<0.05). 2017;9(4):e503. Department of Oral Biology, Dr. Ishrat-Ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Dow University of Health Sciences, Karachi, Pakistan, Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan, Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan, You can also search for this author in This toothpaste contains a unique formula that blocks the pathways to pain instantly Its clinically proven formula provides INSTANT RELIEF from the first usage, LONG-LASTING RELIEF with twice everyday use. In addition, patients were educated regarding the cause of the disease for prevention and awareness of oral hygiene measures, brushing techniques, and dietary influences in DH. A total of 140 met the eligibility criteria with at least two sensitive teeth anterior to molars due to erosions or abrasions with or without an associated gingival recession. Moreover, there was no significant difference between dentifrices containing FCPS, Pro-argin, and 8% strontium acetate (p>0.05) on completion of trial after six weeks. Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. Google Scholar. All rights reserved. Colgate-Palmolive Company 2018. CONCLUSION: The study results support the following conclusions: (1) Colgate Sensitive Pro-Relief toothpaste provides a significantly more reduction in dentin hypersensitivity than Sensodyne. These findings were similar to a previous study conducted by Schiff et al. Anvnd tv gnger dagligen. Toothpaste doesn't only clean your teeth; we have products to help with a variety of tooth issues like sensitivity and more. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. The Gum Health Physical is a new interactive digital tool you can use to quickly evaluate your patients in-office, and give them a personalized report they can use at home. (Table 1) (Fig. Colgate* Sensitive Pro-Relief TM/MC Toothpaste with Pro-Argin TM/MC Technology is the first toothpaste that is clinically proven to provide instant & lasting relief from dentin hypersensitivity. The formula consists of Arginine, an amino acid naturally found in saliva and also calcium from calcium carbonate. We found more change in pain scores of VAS used for mechanical stimuli with Pro-argin than FCPS as shown in Table 5 that could be relatable with a randomised controlled trial of FCPS and arginine based desensitizers reporting better treatment response of arginine than FCPS in the cold stimulated DH after two weeks to one month, subsequently [40]. Colgate Toothpaste relieves the discomfort of tooth irritation by still addressing the root causes. The second objective of the current study was to directly compare the clinical efficacy of FCPS, Pro-argin technology, and strontium acetate-based dentifrices due to their similar mode of action and tubular occluding potential in managing DH [36, 37]. No adverse events like gingival inflammation, bad taste, allergies, fluoride incompatibility, and dental or tongue stains were observed for all dentifrices. 2019;46(12):11216. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth. Docimo R et al. 2017;59(4):4618. For instant relief, apply directly to the sensitive tooth with finger tip, and massage gently for 1 minute, once a week or less frequently. A randomised, controlled, triple-blinded clinical trial was conducted with 140 participants clinically diagnosed with DH and equally randomized into four groups with parallel treatment assignment of FCPS, Pro-Argin, 8% strontium acetate, and sodium fluoride-based OTC dentifrices, and tested for DH with air blast, mechanical, and water jet stimuli on SCHIFF cold air sensitivity scale (SCASS) and visual analogue scale (VAS) at interim efficacy intervals of one minute, three days, two, four, and six weeks, subsequently. The sensitive toothpaste remineralises tooth enamel for more resistance against acid attacks. In addition, one-Way ANOVA with Post Hoc Tukey for pair-wise comparison was used to compare treatment groups computing percent change from baseline with formula (post-application mean scores-baseline mean scores/baseline mean scores). compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. Google Scholar. 2009;22(Spec No. 1997;24(11):80813. COLGATE. 2012;12(3):2208. 0:00 / 0:30 Colgate Sensitive Pro-Relief Challenge Advert April 2012 178,990 views Mar 29, 2012 Take the Colgate Sensitive Pro-Relief Challenge to Show more 15 Dislike Share. Dent Health Curr Res. Two double-blind randomized clinical studies by Nathoo et al. J Clin Dent. There was no statistically significant treatment difference between the two (p=0.499). However, Pro-argin showed more clinical improvement in air blast and mechanically stimulated DH compared to 8% strontium acetate, as shown in Tables 4 and 5. * *With continued use twice a day Prevents sensitivity from coming back* *With continued use twice a day can help prevent sensitivity from coming back. Sealed channels protect against pain caused by hot, cold and sweet stimuli. Help Caregivers Understand Caries | Colgate Professional, compared to a leading brand of desensitizing toothpaste, Colgate Sensitive Pro Relief Repair and Prevent, Colgate Sensitive Pro Relief Enamel Repair, Colgate Sensitive Pro Relief Multi Protection. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth (with continued use twice a day). Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. 2019;40(10):6537 (quiz 8). Colgate Tandpasta Sensitive Instant Relief Whitening. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. Effect of dentin hypersensitivity treatment on oral health related quality of lifea systematic review and meta-analysis. It revealed an immediate improvement with strontium acetate more than Pro-argin on SCASS. 2018. If the enamel is too thin, has tiny tubules that reveal the underlying dentin, or is worn down in some places. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. A head-to-head comparative evaluation of these most effective bioactive agents, such as arginine and BAG-based desensitisers, was suggested by Martins et al. 29,95 kr. The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. 2008;29(8):1S-35S. Samueli A, Hill R, Gillam D. Bioactive glasses in the management of dentine hypersensitivity: a review. YYYY Colgate-Palmolive Company. It also strengthens tooth enamel by helping rebuild weak spots. J Dent. PubMedGoogle Scholar. Size: 75ml (Approx.) J Clin Periodontol. 75 ml. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. PubMed Find products and services. Int J Dent. Innehll Colgate Sensitive Instant Relief Enamel Repair r en fluortandkrm med Pro-Argin-teknologi som ger omedelbar smrtlindring vid ilningar i tnderna. Based on the synthesis of study results, we can conclude that Pro-argin in Colgate Sensitive Pro-relief and 8% strontium acetate in Sensodyne Rapid Action both are effective for pain relief in one minute after application in DH with better immediate treatment response of Pro-argin than strontium acetate. These participants were randomized equally by the principal investigator into four entitled treatment arms using computer-generated random sequence numbers, and treatments were allocated randomly using sequentially numbered, opaque, sealed, and stapled envelopes (SNOSE). Modified bass brushing method was demonstrated on the same model before the first application of dentifrices in the dental clinic. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. In comparison, the Pro-argin can make mechanical barrier of calcium phosphate precipitates on exposed dentinal tubules up to 2m depth by the interaction of positively charged arginine, amino acids and type 1 collagen fibres [8]. Colgate Sensitive Instant Relief Repair & Prevent tandkrm ger dig kliniskt bevisad lngvarig lindring mot ilningar i tta veckor nr du anvnder den tv gnger om dagen. Moreover, the occluding potential of Pro-argin has also been ascertained in a previous in vitro analysis conducted by Lavender et al. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. However, there was no significant treatment difference between dentifrices containing Pro-argin and strontium acetate (p>0.05) at each efficacy interval. Terms and Conditions, Grnberg C, Bauer F, Crispin A, Jakob M, Hickel R, Draenert ME. 2010;21(2):428. In contrast, there was a significant (p<0.001) reduction of 61.1% with FCPS, 60.1% with Pro-argin, 53.4% with 8% strontium acetate, and 25% with NaF-based dentifrices relative to baseline after subsequent six weeks of application observing sustained relief from DH on SCASS. Product Details Page . J Clin Periodontol. While 8% strontium acetate showed a greater clinical reduction in water jet stimulated DH on VAS than Pro-argin at all efficacy intervals, as demonstrated in Table 6. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. 3rd edition, Public Health England 2014. Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Comparative evaluation of desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate: a randomized controlled clinical trial. Lai HY, Lee S, Toh SW, Li Y, Mateo LR, Morrion BM, Zhang Y: The clinical efficacy of a new dentifrice with zinc on plaque and gingivitis. According to Holland's guidelines of conducting a trial for managing DH, two diagnostic tools are sufficient for quantitative assessment of the clinical efficacy of desensitisers. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. * with direct application and daily brushing Benefits Exclusive Pro-Argin formula Prevents sensitivty coming back Pro-argin resulted in the immediate treatment response and statistically significant (p<0.001) clinical reduction in DH than FCPS in the present study, as shown in Table 3. Effectiveness of dentifrices with new formulations for the treatment of dentin hypersensitivitya meta-analysis. 2. With the exclusive Pro-Argin formula, it provides instant* and lasting** relief by plugging the channels to block tooth sensitivity. Am J Dent. Klubpris: 25,46 kr. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth**. Further, it leaves a durable, mineral-enriched layer on the exposed dentin to help protect against future dentin hypersensitivity. [18] in a meta-analysis in 2020. The price for Colgate Sensitive Pro-Relief is set at RM12.80 to avoid being categorized at RM13.00. For lsting relief, apply to a gentle toothbrush making sure to brush all . In our study, patient compliance related to the recommended time of application and method of the application provided by doctors was controlled by subjecting multiple efficacy intervals and different methods for assessment of the change in pain scores due to DH. The secondary objective of the study was to compare the clinical efficacy of Pro-argin, strontium acetate, and FCPS for immediate and sustained treatment response in DH that was measured on SCASS as a primary outcome measure and VAS as secondary outcome measure at efficacy intervals of one minute, day-three, week two, four and six. The effectiveness of Colgate SENSITIVE INSTANT Relief toothpaste is built on its Pro-Argin technology with arginine and calcium from calcium carbonate. KruskalWallis test was used to compare treatment groups. Colgate Sensitive Pro-Relief toothpastes have been formulated to provide instant and lasting relief from the pain associated with sensitive teeth. J Non Cryst Solids. A total of 140 participants were initially enrolled and randomised into the four treatment arms, with thirty-five in each group. . Colgate Sensitive Pro-Relief Original Toothpaste This toothpaste gives you the freedom to forget about tooth sensitivity. Docimo R, Montesani L, Maturo P, Costacurta M, Bartolino M, DeVizio W, Zhang YP, Cummins D, Dibart S, Mateo LR: Comparing the Efficacy in Reducing Dentine Hypersensitivity of a New Toothpaste Containing 8.0% Arginine, Calcium Carbonate, and 1450 ppm Fluoride to a Commercial Sensitive Toothpaste Containing 2% Potassium Ion: An Eight-Week Clinical Study in Rome, Italy. Apotekets varuid 29483 Varunummer 207000 Kategori Tandkrm, Ilningar i tnderna Varumrke J Dent. [41] was performed in 2017 and reported inappropriate statistical methodologies related to the normal distribution of data and equality of variances, along with lacking information in 77.1% of the thirty-five randomised trials on DH management. The clinical significance of this study can be highlighted by the fact that this was a person-centred clinical trial where patients were the prime focus where thepatients suffering from DH. The Sensitive Pro-Relief Multi-Protection toothpaste by Colgate thoroughly cleans your teeth, while providing you with relief from sensitive tooth pain. It is clinically proven for instant and lasting Sensitivity relief* How does it work? J Dent. Significantly greater sensitivity reduction with twice - daily brushing compared to control toothpaste with potassium ions. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. West N, Newcombe RG, Hughes N, Mason S, Maggio B, Sufi F, et al. Correspondence to Pro-Argin technology can be found in Colgate Sensitive Pro Relief Toothpaste, sold as Colgate Sensitive Instant Relief in the UK and elmex Sensitive Professional in Europe. Formulated with Pro-Argin technology, Colgate Sensitive Pro-Relief is clinically proven instant and lasting sensitivity relief*. PubMed Central Vu Pham T, Anh Nguyen T. Clinical evaluation of the desensitizing efficacy of a paste containing 8% arginine and calcium carbonate. Dentine Hypersensitivity. Purchased in August 2019 at Coles for $5. Privacy The impact of FCPS, Pro-argin, and strontium acetate-based treatments of DH on the oral health-related quality of life together with the difference in the effectiveness of treatments were assessed individually rather than in groups in the current six-week trial. Helps restore natural whiteness of teeth. Am J Dent. Martins CC, Firmino RT, Riva JJ, Ge L, Carrasco-Labra A, Brignardello-Petersen R, et al. A randomised clinical trial on the efficacy of 5% fluorocalcium phosphosilicate-containing novel bioactive glass toothpaste. This site is intended for healthcare professionals only. Last updated on May 11, 2021. ID: NCT04249336 (https://clinicaltrials.gov/ct2/show/NCT04249336), Date of Registration: January 30, 2020 (Retrospectively registered). The sealed envelope contained details of unique subject numbers assigned individually in ascending order, group titles, and treatment codes and was placed in the box. Colgate Sensitive Pro Relief Enamel Repair to strengthen weakened enamel and prevent enamel loss. Published literature [16, 31, 43] has determined that all previous trials on treating DH were conducted on smaller samples, which might have prevented the results from being extrapolated on the general population. With regular use, the Pro-Argin formula builds a long-lasting protective barrier that acts like a seal against sensitivity. Colgate Sensitive Pro-Relief toothpaste is a revolutionary and one-of-its kind remedy that can provide consumers suffering from Sensitivity the much needed instant and long lasting relief . J Evid Based Dent Pract. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. Internal report 2018, 5. Oral dentifrices have been marketed for pain relief within a minute for DH. 2015;28(1):404. The sensitive toothpaste works in different ways to fight cavities, remove plaque, promote gum health and freshen breath. However, we can conclude that both Pro-argin and strontium acetate-based dentifrices disrupt the pathophysiology of DH and are effective for immediate pain relief even one minute after application on sensitive teeth. Colgate SENSITIVE INSTANT Relief Repair & Prevent toothpaste with PRO-ARGIN Technology and Zinc provides clinically proven instant* and lasting sensitivity relief1-2 plus lasting gum protection3. Shiau HJ. Saba Arshad. All rights reserved. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. Plain bi-carb soda and coconut butter do a far better job at cleaning and desensitising. SEALS & REPAIRS: Pro-Argin technology helps to seal and repair the sensitive areas of teeth. The Colgate Sensitive Pro Relief range features toothpastes that provide relief for sensitive teeth while addressing other common oral health concerns: Colgate Sensitive Pro Relief Repair and Prevent to protect against gingival recession. 2010;21(2):568. Lg i kurv. The current study outcomes showed significant decrease in pain scores of air-blasts and water jet stimulated DH with FCPS based dentifrices compared to Pro-argin and 8% strontium acetate after two, four, and six weeks subsequently, as depicted in Tables 4 and 5. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Ashwini S, Swatika K, Kamala DN. All participants were instructed to dry the tooth surface with the cotton ball and apply a paste of about half-inch length on the dried surface for one minute, then brush the teeth twice daily after breakfast and before sleep as per directions demonstratedon the study model. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. found the clinical efficacy of Pro-argin better than strontium acetate for mechanical and air-blast stimulated DH on VAS and SCASS in follow-up periods of one minute, three days, two, four and eight weeks in a systematic review in 2015. Besides, these findings of the current study could be related to previously conducted clinical trials indicating the better clinical effectiveness of Pro-argin than strontium acetate against air-blast and tactile stimulus after three days and one week of application [30, 31]. Colgate Sensitive Pro-Relief (Toothpaste): 1.9 out of 5 stars from 91 genuine reviews on Australia's largest opinion site ProductReview.com.au. DH most commonly involves the facial surfaces of maxillary and mandibular permanent teeth. 7 Ipsos, UK Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2 weeks trial, 192 respondents, 2016. Participants were asked to pick up the envelope from the box. Oral Care Products | Colgate Professional, Colgate Toothpaste - Dentists & Patients | Colgate Professional, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste, Instantly* relieves dentine hypersensitivity, Long-lasting relief from the pain of sensitive teeth, Helps strengthen gums and prevent gum recession, Recommended fluoride level for caries protection (1450ppm). How does Colgate Sensitive Pro-Relief Repair & Prevent work? Sriranganathan D, Chen X, Hing KA, Kanwal N, Hill RG. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste with Pro-Argin Technology and Zinc. Helps protect teeth against cavities and promotes healthy gums (with regular brushing). 1). Oral dentifrices have been marketed extensively for pain relief in one minute after topical application on sensitive teeth, with the claims of several dentists recommending the formulations containing Pro-argin and 8% strontium acetate. A meta-analysis by Yang et al. Helps repair teeth by forming a mineral layer that re-constructs the sensitive part of the tooth, with regular use; Seals the open nerve channels for instant relief, and helps prevent sensitivity from re-occurring; Plus the freshness you trust from Colgate 2023 BioMed Central Ltd unless otherwise stated. Trials. Bae J-H, Kim Y-K, Myung S-K. Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. Yang ZY, Wang F, Lu K, Li YH, Zhou Z. Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis. YYYY Colgate-Palmolive Company. Desensitizing toothpastes for dentin hypersensitivity: a network meta-analysis. The treatment difference between Pro-argin and 8% strontium acetate was not statistically significant with a p>0.05 for immediate and sustained pain relief in DH and statistically significant relative to control on all clinical parameters of the SCASS and VAS. Dentifrices were removed carefully after one minute of undisturbed application by rinsing the air lightly with an air syringe, and the subject was asked to spit. Thank you for your feedback. We were using the PAS version.11, two independent sample t-test with 95% confidence interval and 80% power of test, meanSD of air blast stimulus test score of test group 1.860.41 and control group 2.220.41 two weeks after baseline test score, the calculated sample size was 22 [21] which was raised to 35 including five as drop out for each group (Fig. Yes, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste should be used for twice daily toothbrushing to provide ongoing relief from the pain of sensitive teeth. Colgate Sensitive Pro-Relief Whitening Toothpaste provides clinically proven instant and lasting relief for sensitive teeth. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The authors declare that they have no competing interests (financial and non-financial) related to the article. Benefits. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . IRB-1351/DUHS/Approval/2019/184. 2018;75:1221. These then interact to form a complex with positive charge. By using this website, you agree to our California Privacy Statement, Therefore, the current study outcomes were analysed by parametric and non-parametric statistical tests after assessing the normal distribution of data and equality of variances with Shapiro Wilk statistics. 2017;457:2530. It remains a prevalent global disease with two different treatment modalities of home-care desensitisation with the over-the-counter (OTC) desensitisers such as potassium, IADR, The Excel, United Kingdom. Colgate Sensitive Pro-Relief Multi Protection Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily SHOULD A PATIENT CONTINUE USING Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE ONCE THE DENTINE SENSITIVITY HAS GONE? Colgate Sensitive Pro-Relief Instant Relief Sensitive Toothpaste - 75ml More Images Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Lai et al. Oral dentifrices were provided to the subject free of cost. Canines and premolars are the most commonly affected teeth among 2530% of the adult population [2]. Pessoa OF, Loretto SC, Maia LC. it is in a rubbish bin now. Compend Contin Educ Dent. 4Intervention D denotes Colgate Total. [33] again reported a 54% clinical reduction in DH with Pro-argin in eight weeks clinical trial using SCASS. compared Colgate Sensitive Pro Relief to another leading brand that desensitizes with a 2% potassium ion formula. The second null hypothesis was that mean scores for pain due to DH among different treatment groups for sustained relief remains the same, and it was considered to be rejected at a p value0.05. Ingredients *Calcium carbonate *Water Post-application changes on SCASS were observed after one minute, three days, two, four, and six weeks, subsequently. Compared to stannous fluoride/sodium fluoride and novamin/sodium fluoride. Lavender SA, Petrou I, Heu R, Stranick MA, Cummins D, Kilpatrick-Liverman L, et al. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. SCASS and VAS were introduced on each visit as primary and secondary outcome measures, respectively. 2016;27(4):916. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. BMC Oral Health It contains clinically proven Pro-Argin technology which provides instant and lasting sensitivity relief. This trial was registered in an ICMJE approved registry at https://clinicaltrials.gov/) under protocol Identifier: NCT04249336 [19] following the CONSORT guidelines [20] for parallel-group randomized trials after approval from the Institutional Review Board of Dow University of Health Sciences with reference no. This clinical trial has not included a run-in or washout period before the test phase due to time constraints and compliance of the potential participants. Elsevier; 2015. p. 3344. Nathoo S et al. Colgate Sensitive Pro-relief Instant Relief. PubMed 1. 2010;23(Spec No A):14A-9A. Colgate Sensitive Pro-Relief efektywnie i szybko znosi nadwraliwo zbw, zamyka kanaliki zbinowe w ktrych s zakoczenia nerww, dziki czemu blokuje bl. The Pro-Argin technology repairs sensitive areas of the teeth for instant* and long-lasting sensitivity pain relief. Article Desensitizing toothpastes depolarize the nerves to reduce pain signals to the brain, while occlusives block the dentin tubules to prevent painful stimuli affecting dentinal fluids. Gently and effectively removes stains. Colgate Sensitive Pro Relief was compared to a leading brand of desensitizing toothpaste containing stannous fluoride in a laboratory study, with confocal laser scanning microscopy and a novel imaging program used to qualify dentinal tubule occlusion. J Clin Dent 20 (2009), special issue 17-22, 3. SJAZ has contributed to the conception, design, interpretation of results and critically revised the manuscript. Dentin hypersensitivity treatments work in one of two ways.